E.E.(Electrical Engineering): Universidade de São Paulo (USP), Escola Politécnica, Dec. 1973
M.S.E.E. : Universidade de São Paulo (USP), 1976 (research on computerized electrocochleography)
Ph.D. : University of California at Los Angeles (UCLA), 1980 (research on the communication across an inhibitory synapse in crayfish and in eletronic and mathematical models)
Professor of Biomedical Engineering at USP
Founder and co-Director of the Biomedical Engineering Laboratory at USP
Member of the campus-wide Neuroscience graduate program at USP
Researcher at the National Institutes of Health (NINDS) from 10/1994 to 4/1995
Human Neurophysiology with Emphasis on the Spinal Cord
Modeling and Simulation of Neurons and Neuronal Networks
Motor Control in Humans and Animals
Biomedical Signal Processing
and Pattern Recognition
MS and Ph.D. advisor
I advise students from engineering, physics, computer science and equivalent backgrounds in the Electrical Engineering Program of the Escola Politécnica da USP (http://www.pcs.usp.br/~posgrad-eletrica/). These students usually do research on the mathematical modelling of neurons and their networks, synapses, muscles and the complex interactions of all these elements together. One of the goals is to increase knowledge related to motor control at different levels of organization.
I also advise students from biomedical sciences backgrounds in the campus-wide Neurosciences Program (http://www.ip.usp.br/portal/index.php?option=com_content&view=article&id=949%3Aapresentacao-do-programa-de-pos-graduacao-em-neurociencias-e-comportamento&catid=252&Itemid=114&lang=pt). These students do experimental work dealing with human motor control and human spinal cord.
Papers and Book Chapters
Elias, F.H. Magalhães,
and A.F. Kohn (2013). Experimental
and Simulated EMG Responses in the Study of the Human
Spinal Cord "Electrodiagnosis in New
Frontiers of Clinical Research", book
edited by Hande Turker, ISBN 978-953-51-1118-4,
Published: May 22, 2013 under CC BY 3.0 license
D.R. Toledo and A.F. Kohn (2013). Plantar
flexion force induced by amplitude-modulated tendon
vibration and associated soleus V/F-waves as an
evidence of a centrally-mediated mechanism
contributing to extra torque generation in
of NeuroEngineering and Rehabilitation 2013,
L.A. Elias and A.F. Kohn (2013). Individual and collective properties of computationally efficient motoneuron models of types S and F with active dendrites Neurocomputing - Volume 99, 1 January 2013, Pages 521–533
R. A. Mezzarane, A. F. Kohn, E. Couto-Roldan, L. Martinez, A. Flores and E. Majarrez (2012) Absence of effects of contralateral group I muscle afferents on presynaptic inhibition of Ia terminals in humans and cats JOURNAL OF NEUROPHYSIOLOGY August 15, 2012 vol. 108 no. 4 1176-1185
L.A. Elias, V.M
Chaud and A.F. Kohn (2012). Models of passive and active
dendrite motoneuron pools and their differences
in muscle force control Journal of
December 2012, Volume 33, Issue 3, pp 515-531.
F.H. Magalhães and A.F. Kohn (2012). Imperceptible electrical noise attenuates isometric plantar flexion force fluctuations with correlated reductions in postural sway. EXP.BRAIN RES. 2012 Mar;217(2):175-186. Epub 2011 Dec 24.
F.H. Magalhães and A.F. Kohn (2011). Vibratory noise to the fingertip enhances balance improvement associated with light touch. EXP.BRAIN RES. 209, 139-151.
and A.F. Kohn (2011). Vibration-enhanced
achieved by tactile supplementation: May blind
individuals get extra benefits? Med Hypotheses. 2011 May 20.
P. H. Marchetti,
A. F. Kohn and M. Duarte (2011). Selective
activation of the rectus abdominis muscle during
low-intensity and fatiguing tasks. Journal of Sports Science
F.H. Magalhães and A.F. Kohn (2010). Vibration-induced extra torque during electrically-evoked contractions of the human calf muscles. J. Neuroengineering and Rehabilitation, 7:26
R. A. Mezzarane and A. F. Kohn (2009) A method to estimate EMG crosstalk between two muscles based on the silent period following an H-reflex. Medical Engineering & Physics 31 (2009) 1331-1336
R. A. Mezzarane and A. F. Kohn (2008) Postural control during kneeling. Exp Brain Res (2008) 187:395–405. DOI 10.1007/s00221-008-1308-x
M.C.S. Fornari and A.F. Kohn (2008). High frequency tendon reflexes in the human soleus muscle. NEUROSCIENCE LETTERS, v. 440, p. 193-196. DOI 10.1016/j.neulet.2008.05.075.
R.R.L. Cisi and A.F. Kohn (2008). Simulation system of spinal cord motor nuclei and associated nerves and muscles, in a web-based architecture. JOURNAL OF COMPUTATIONAL NEUROSCIENCE, 25, 520-542. DOI 10.1007/s10827-008-0092-8.
R.A. Mezzarane and A.F. Kohn (2007). Control of upright stance over inclined surfaces. EXPERIMENTAL BRAIN RESEARCH, 180, 377-388.
M.F. Vieira and A.F. Kohn (2007). Compartmental models of mammalian motoneurons of types S, FR and FF and their computer simulation .COMPUTERS IN BIOLOGY AND MEDICINE, 37, 842-860.
A.F. Kohn(2006). Autocorrelation and Cross-correlation Methods .Wiley Encyclopedia of Biomedical Engineering, Ed. Metin Akay. New Jersey: John Wiley & Sons, 23 pp.
A.F. Kohn (2005). Cross-correlation between EMG and center of gravity during quiet stance: theory and simulations. BIOLOGICAL CYBERNETICS, 93, 382-388.
E. Manjarrez, Z. Hernández-Paxtián and A.F. Kohn
in cats. JOURNAL OF NEUROPHYSIOLOGY, 94,
L.M. Lucchesi, S. Pompéia, G.M. Manzano, A.F. Kohn, J.C. Galduroz, O.F.A. Bueno and S. Tufik (2003). Flunitrazepam-induced changes in neurophysiological, behavioural and subjective measures used to assess sedation. PROG NEURO-PSYCHOPHARMACOL BIOL PSYCHIAT, 27, 525-533.
A.F. Kohn e M.F. Vieira (2002). Optimality in the encoding/decoding relations of motoneurones and muscle units. BIOSYSTEMS, 67, 113-119.
R.A. Mezzarane and A.F. Kohn (2002). Bilateral soleus H-reflexes in humans elicited by simultaneous trains of stimuli: symmetry, variability and covariance. JOURNAL OF NEUROPHYSIOLOGY, 87, 2074-2083.
G.M. Manzano and A.F. Kohn (2000). Proximal receptors and the mechanical stimulation of the fingers: a somatosensory evoked potential study. Electromyogr. Clin. Neurophysiol, 40, 21-29.
D.G. Goroso, R.R.L. Cisi and A.F. Kohn (2000). The amplitude and phase responses of the firing rates of some motoneuron models. BIOSYSTEMS, 58, 33-39.
A. F. Kohn (1998). Effects of synaptic noise on a neuronal pool model with strong excitatory drive and recurrent inhibition. BIOSYSTEMS, 48, 113-121.
A.F. Kohn, M.K. Floeter and M. Hallett (1997). Presynaptic inhibition compared with homosynaptic depression as an explanation for soleus H reflex depression in humans. EXP. BRAIN RES., 116, 375-380.
M. K. Floeter and A. F. Kohn (1997). H reflexes of different sizes exhibit differential sensitivity to low frequency depression. Electroenceph. Clin. Neurophysiol (Electromyography and motor control), 105, 470-475.
A. F. Kohn (1997). Computer simulations of noise resulting from random synaptic activities. Comput. Biol. Med., 27, 293-308.
A.F. Kohn, L.G.M. Nakano, M. Oliveira and Silva (1996). A class discriminability measure based on feature space partitioning. Pattern Recognition, 29, 873-887.
A.F. Kohn and S. S. Furuie (1991). Safety in medical signal analysis. I.E.E.E. ENG. MED. BIOL. MAG., 10, pages 56 and 62.
A.F. Kohn (1989). A versatile waveform generator for testing neuroeletric signal processors. J. NEUROSCI. METH., 29, 157-163.
A.F. Kohn (1989). Dendritic transformations on random synaptic inputs as measured from a neuron's spike train - Modeling and simulation. I.E.E.E. TRANS. BIOMED. ENG., 36, 44-54.
A.F. Kohn (1987). Phase distortion in biological signal analysis caused by linear phase FIR filters. MED. BIOL. ENG. COMP., 25, 231-238.
O.D.Martinez, A.F.Kohn and J.P.Segundo (1983). Pervasive locking, saturation, asymmetric rate sensitivity and double- valuedness in crayfish strech-receptors. BIOL. CYBERN., 49, 33-45.
A.F.Kohn and J.P.Segundo (1983). Neuromime and computer simulations of synaptic interactions between pacemakers. Mathematical expansions of existing models. J. THEOR. NEUROBIOL., 2, 101-125.
A.F.Kohn, A.F.Rocha and J.P.Segundo (1981). Presynaptic irregularity and pacemaker inhibition. BIOL. CYBERN., 41, 5-18.
J.P.Segundo and A.F.Kohn (1981). A model of excitatory synaptic interactions between pacemakers. Its reality, its generality and the principles involved. BIOL. CYBERN., 40, 113-126.
Livro em pdf disponível para os interessados. Clique aqui para fazer o download.
Selected Conference Publications
R.R.L. Cisi and A.F. Kohn (2008). From neuronal ionic channels to muscle control: a Web-based simulator and its application to teaching. World Congress of Engineering /International Conference on Systems Biology and Bioengineering. London, pp 1-4.
A.F. Kohn (2007). Estimation of neural noise spectrum in a postural control model. IFMBE Proceedings, vol. 16, of the 11th Mediterranean Conference on Medical and Biological Engineering (Ljubljana, Slovenia), 419-422.
L.A. Okai e A.F. Kohn (2006). The influence of the flexor digitorum brevis muscle on postural stability. XVI Congress of the International Society of Electrophysiology and Kinesiology (Torino, Italy), pp 1.
R.R.L.Cisi and A.F. Kohn (2004). Spinal Cord Neuronal Network Simulator. Proceedings of the 28th Conference of the Canadian Medical and Biological Engineering Society (Quebec, Canadá), CD-ROM, pp 1-3.
A.F. Kohn, M. K. Floeter and M. Hallett (1995). A
model-based approach for the quantification of H reflex
depression in humans. 17th Annual International
Conference of the IEEE Engineering in Medicine and Biology
Society (Montreal, Canada).
Specific Research Interests
Spinal cord neurophysiology
studied by means of the analysis of postural and
reflex dynamics. Analysis of the electrical activity of
muscles, nerves and the brain for research and clinical
diagnosis. Mathematical modeling and simulation of
neurons, synapses and neuronal networks of the spinal
Some Activities at the University of Sao Paulo
Teaching undergraduate and graduate courses, e.g., Signals and Systems I and II, Fundamentals of Neuroscience, Spinal Cord Neurophysiology, Neurophysiology of Motor Control, Digital Signal Processing, Biological Signal Processing. Advising undergraduate and graduate students (from the biomedical and the hard sciences) on human neurophysiology and on neuronal modeling and simulation. Coordinating many of the activities of the lab.
H-reflex, presynaptic and reciprocal inhibition in humans, bilateral reflexes; postural control; evoked brain potentials; human electromyography; digital signal processing and pattern recognition applied to neuroelectric signals; modeling and simulation of neurons and neuronal networks; biomedical instrumentation; crayfish inhibitory synapse and stretch receptor dynamics.
pictures taken from our neurophysiology lab
Recipient of the Ralph Crump Award for Excellence in Medical Engineering at UCLA in 1980. Member of the CNPq (Brazilian N.S.F.) National Committee for Electrical and Biomedical Engineering from 1991 to 1993 and 2005 to 2007. Member of Scientific Committees of national and international Conferences on Biomedical Engineering and Neuronal Modeling.
Eco-travel to wonderful forests, mountains, waterfalls and beaches in Brazil. Watching/listening DVDs and CDs (pop/rock, classical, jazz), reading books, barbecue activities.
Universidade de São Paulo,
Escola Politécnica, PTC
CEP 05424-970, São Paulo, S.P., Brasil
or (a non-post office box address):
de São Paulo,
Escola Politécnica, PTC
Av. Prof. Luciano Gualberto, Trav 3, 158
CEP 05508-900, São Paulo, S.P., Brasil
or if you come personally:
room D2-09 of block D
at the Electrical Engineering Building